According to the records of Chinese history, Huatuo, a well-known doctor of ancient China, once invented narcotic, and it was succeeded in using in the surgery. China’s historical book, The Records of Three Kingdoms, once recorded:” If disease is situated in the place that the medicine can’t reach, then must perform the operation. Let patient drink narcotic, the patient will lose consciousness after a moment. Thus the patient will not feel pain.” Narcotic is known as “Mafeisan” in ancient China. It is a kind of narcotic which people can drink. It is more comfortable and more convenient than the modern narcotic method. However, its formula had been lost. Besides, because lack historical data, ancient Chinese narcotic has already become a permanent mystery!